When correcting for site + age + sex + CV risk factors (without blood pressure), the association of est24hNa (per 1000 mg) with carotid plaques remained significant (OR: 1.04 95%CI: 1.01-1.07 P=0.017).
Similar associations were obtained when corrections for site + age + sex were included (OR: 1.03 95%CI: 1.00-1.06 P=0.028 for carotid plaques OR: 1.04 95%CI: 1.01-1.07 P=0.016 for CACS 1.04 95%CI: 1.01-1.07 P=0.020 for coronary artery stenosis), but these associations were abolished with additional corrections for blood pressure.There was a significant association between each 1000 mg increase in est24hNa and increased occurrence of carotid plaques (OR: 1.09, 95%CI: 1.06-1.12 PThe main outcome was the presence of carotid plaques, coronary artery calcification (CACS) or coronary artery stenosis. Carotid atherosclerosis was determined from ultrasound images (n=10,700). Coronary atherosclerosis was determined with coronary CT angiography (CCTA n=9623) and coronary artery calcium score (CACS n=10,289). Sodium intake was determined by calculating an estimated 24h sodium excretion (est24hNA) with the Kawasaki formula. In this analysis, 10,764 participants (mean age 58 years, 52% woman) from 2 different university hospitals were included, who had additional measurements for urinary sodium and creatine.
This cohort comprised of 30,154 participants of the general Swedish population aged from 50-64 years, who underwent detailed characterization of atherosclerosis in the coronary and carotid arteries. The authors investigated whether there is an association between salt intake and coronary or carotid atherosclerosis in the general Swedish population.ĭata from the Swedish Cardiopulmonary bioImage Study (SCAPIS) cohort were used in this study. It remains unclear whether there is an association between salt intake and coronary atherosclerosis. Previous research suggests that there is an association of salt intake with vascular damage and the development of peripheral atherosclerosis. High dietary sodium intake increases blood pressure and the risk of CVD.
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